Halo: Reach looks fun.
FFXIV beta is fun.
CoD: Black Ops looks great.
Fallout: New Vegas is going to be good.
Portal 2 will definitely be good.
Diablo III I've been waiting for for a long time.
Dead Rising 2 looks very good.
Borderlands was always fun, need to play old DLC though.
Ooh, and Castlevania: Lords of Shadow.
And despite it probably not coming out till next year, MGS: Rising is definitely something to watch for due to it being MGS. And having cyborg Raiden.
And I didn't know there was another Batman game coming out. Have to play Arkham Asylum some time.

my list of upcoming games was just as big at the beginning of the year...and school's starting really soon (two days).
[Edit]
OH! I forgot! Vanquish!
Based on the list of games you came up with, my picks are:
- Batman: Arkham City (I absolutely loved Arkham Asylum)
- Portal 2
- Fallout: New Vegas
- Call of Duty: Black Ops
Other games I'm looking forward to are:
Deus Ex: Human Revolution
Rage
Brink
Bioshock Infinite
Battlefield 3 (yep, I'm eagerly awaiting this game -- long time fan of the Battlefield series)
I doubt some of those will come out soon, but sure, why not.
Can't wait for new Deus Ex, Battlefield 3(ever since I got 2142, I've loved Battlefield) and Bioshock Infinite.
[Edit]
And if some time between late this year and April counts, I wants me some 3DS launch titles.