I'm a fan of the "Reopen the pages that were open last" option...
With Chrome I see no need to set Google as my home page as I can simply hit Ctrl+T (for a new tab), start typing, hit enter, and BAM!! Google search results.
Since I have my tabs open from last time, it is to be presumed that a home page (some place you would go to often) would already be open from last time. That way, when I open my browser, I have my e-mail, Facebook, the eGO website, and anything else open already.
So, I guess you could say I have multiple home pages...