I don't know if it would work in every game, but cell-shading makes some games stand out. The recent Prince of Persia had a sickly sweet cell-shaded style, and what I've seen of the soon-to-be-release Borderlands looks pretty interesting, too.
That's not exactly cell-shading though. That's just increasing the thickness of outlines on the player model. To be cell-shaded, the detail textures would need to be replaced with single-color textures.