Yea we need some more info before we can help you.
What operating system (XP, Vista, 7?) also, 32bit or 64bit.
I myselft had a lot of trouble getting 2142 to work on 64bit Vista, but I had no problem on 64bit Windows 7.
The thing that worked for me on Vista was to disable the UAC. Be sure that you have the latest version (1.5) of 2142, and also try updating your PB with PBsetup.