I've lived in Orlando for about 11 years, and it's not bad...for a tourist, lol. Of course, some of the locations like trykael said are self-explanatory, and plenty depend on the age of the children.
During the one-week in Orlando, I'd suggest checking out at least one of the amusement parks. I personally prefer Universal over Disney, because It would be much cheaper (2 Park 1 Day ticket $75 each and 2 Park Unlimited Week $80 each online) as opposed to Disney's $71 each for one day ages 10+.
Theme parks aside, there are also a few little places you can go, many of them you can find on International Drive. I'd check out WonderWorks if you can. It has some interesting things in there, and if you are near the downtown area, I'd also take a peek at the Orlando Science Center. Sure, it may sound nerdy, but I loved going there as a kid, because many of the things there are interactive.
I'm sure there's plenty I left out.
